For stability analysis, fexofenadine enantiomers (0
The stereoselective pharmacokinetics of fexofenadine are associated with OATP2B1
Purpose We examined the effect of a single apple juice intake on the pharmacokinetics of fexofenadine enantiomers in healthy Japanese subjects
5% KH 2 PO 4 –acetonitrile (65:35, v/v) on a Chiral CD-Ph column at a flow rate of 0
This study investigated an association of SLCO (encoding organic anion-transporting polypeptides (OATP), 1B1, 1B3, and 2B1), ABCB1 (P-glycoprotein (P-gp)), ABCC2 multidrug resistance protein 2 (MRP2), and ABCG2 (breast cancer resistance protein (BCRP)) polymorphisms with fexofenadine enantiomer pharmacokinetics after an oral dose of
A 63:37 steady-state ratio of R-(+)-1 and S-(−)-1 was observed in plasma and this remained constant across time and dosing
Methods
It is FDA approved to treat seasonal allergic rhinitis and chronic idiopathic urticaria
Aims: The aim was to compare possible effects of verapamil, as a P-glycoprotein (P-gp) inhibitor, on the pharmacokinetics of each fexofenadine enantiomer, as a P-gp substrate
This work aimed to investigate the transplacental pharmacokinetics of fexofenadine enantiomers with and without the selective P-gp inhibitor fluoxetine
In this randomized, two-phase, double-blind crossover study, 10 healthy volunteers received rifampicin 450 mg/day or placebo for 7 days
• Although itraconazole co-administration is known to increase the bioavailability of a racemic mixture of fexofenadine, little is known about the
The Fexofenadine enantiomers were separated using a mobile phase of 0
AUC0-∞, CL/F and CLr for fexofenadine enantiomers in parturient women following a single oral dose of 60 mg racemic fexofenadine hydrochloride (Control group; n = 8) or a single oral dose of 40 In the present paper, we will approach the problem of distinguishing enantiomers using their spectroscopic properties from a theoretical and computational perspective